Publikationslista för Magnus Odén - Publication List : Epress : LiU.se

Targeted delivery of a novel anticancer compound anisomelic

Targeted delivery of a novel anticancer compound anisomelic acid using acid functionalized mesoporous silica catalysts for esterification of fatty acids. 19 Feb 2018 acetoxy malabaric acid and anisomelol are isolated as macrocyclic diterpenes, while anisomelic acid, ovatodlolide are as diterpenoid lactones, 19 Dec 2013 Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic 8 Jul 2014 acid activates the PKR pathway and induces apoptosis through diterpenoid anisomelic acid causes depletion of E6 and E7 viral. 20 Jan 2009 Mohammad A. Akbarsha, Sakari Hietanen, John E. Eriksson, Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 24 Jun 2019 amines, acid anhydride and carboxylic compounds. Characterization revealed the presence of phyto compound such as aniso melic acid, 22 May 2019 as anisomelic acid, anisomeloide, ovatodiolide, 2-acetoxymalabaric acid, anisomelyl acetate anisomelin, betulinic acid, citral, gerainic acid, 24 Nov 2017 Novel action modality of the diterpenoid anisomelic acid causes depletion · of E6 and E7 viral oncoproteins in HPV-transformed cervical Aldrich-331562; Cyclohexanepentanoic acid 0.98; CAS No.: 5962-88-9; Synonyms: 5-Cyclohexylvaleric acid; Linear Formula: C6H11(CH2)4CO2H; Empirical 30 Jul 2018 Title: Synthesis and evaluation of anisomelic acid like compounds for the treatment of HPV-mediated carcinomas. Yury Brusentsev, Abo may be due to the presence of volatile compounds such as anisomelic acid, betulinic acid, citral, gerainic acid and ovatodiolide in the plant extract (Guha Bakshi Pharmaceutical compositions of anisomelic acid and their use Download PDF pharmaceutical composition: cells: antiviral: apoptosis: anisomelic acid; Prior art Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas.

Anisomelic acid

Anisomelic acid | C20H26O4 | CID 5358705 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities 2019-12-30 2019-12-30 Anisomelic acid (AA) is a macrocyclic cembranolide compound extracted from Anisomeles herbal species. Recently, we have shown that AA possesses both anticancer and antiviral activity. However, to date, the plasma protein binding properties of AA are unknown. Here, we describe the molecular interactions of AA with two serum proteins, human serum albumin (HSA) and bovine serum albumin … 1987-01-01 Our earlier research on the cembranoid, anisomelic acid (AA) showed that, AA has the potential to induce apoptosis in HPV cells by the depletion of E6 and E7 oncoproteins. ANISOMELIC ACID.

Fang Cheng - CONVERIS forskningsinformationssystem - Converis

Our recent studies have demonstrated that a plant-derived diterpenoid compound, anisomelic acid (AA), induces apoptosis in cervical cancer cells. In this work, we describe the development of a folic acid (FA)-targeted AA delivery system using chitosan-coated rod-shaped mesoporous silica particles (Chitosan-NR-MSP). diterpenoids – 4, 7 – oxycyclo anisomelic acid, 4 – methylene – 5 – hydroxy ovatodiolide (I), 4 – methylene – 5 – oxo anisomelic acid.

Bsa protein - Bästa benskydden till häst

S1†) is a diterpenoid compound isolated from the medicinal plant Anisomeles malabarica, 7 which we have previously shown to be cytotoxic to oral and cervical cancer cells. 8 Recently, we have shown that AA induces apoptosis and cause cell cycle arrest in SiHa cervical cancer cells by specifically down-regulating the Anisomelic acid (AA), one of the major compounds in Anisomeles malabarica, was tested for its cytotoxicity and apoptosis-inducing potential in breast and cervical cancer cells. The MTT assay for Anisomelic acid, is one of the major compounds in Anisomeles malabarica (L.) R. Br., is a cembrane type diterpenoid, which can be synthesized chemically.

Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 and E7 viral oncoproteins in HPV-transformed cervical carcinoma cells. CAM, cIAP2, HPV: 5 : 2013: Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica. A pharmaceutical composition for anti-viral cancer treatment in mammals, comprising a therapeutically effective amount of Anisomelic acid or salts thereof. The pharmaceutical composition may comprise Anisomelic acid or salt thereof in an oil-in-water emulsion, for example in an isotropic mixture of at least one oil and at least one surfactant or, alternatively, in a hydrophilic solvent and a Anisomelic acid, is one of the major compounds in Anisomeles malabarica (L.) R. Br., is a cembrane type diterpenoid, which can be synthesized chemically. Anisomeles malabarica (Lamiaceae) is an aromatic, densely pubescent, perennial herb, 1.2-2 m in height.
Bokföra pensionsavsättning enskild firma

2. Anisomelic acid (AA) (Fig. S1†) is a diterpenoid compound isolated from the medicinal plant Anisomeles malabarica, 7 which we have previously shown to be cytotoxic to oral and cervical cancer cells. 8 Recently, we have shown that AA induces apoptosis and cause cell cycle arrest in SiHa cervical cancer cells by specifically down-regulating the viral oncoproteins, E6 and E6, 9,10 which are the Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect A pharmaceutical composition for anti-viral cancer treatment in mammals, comprising a therapeutically effective amount of Anisomelic acid or salts thereof.

However, to date, the plasma protein binding properties of AA are unknown. Here, we describe the molecular interactions of AA with two serum proteins, human serum albumin (HSA) and bovine serum albumin (BSA Anisomelic acid (AA) is one of the principle bioactive compounds isolated from the plant Anisomeles mal - abarica . Recently, we have studied the mode of action of AA-mediated apoptosis Synthesis and evaluation of anisomelic acid like compounds for the treatment of HPV-mediated carcinomas Annual Congress on Medicinal Chemistry, Pharmacology and toxicology July 30 - 31 , 2018 Amsterdam , Netherlands. Rajendran Senthilkumar, Yury Brusentsev, Preethy Paul, Fang Cheng, Maria Sippola-Thiele, Patrik Eklund and John E Eriksson Our earlier research on the cembranoid, anisomelic acid (AA) showed that, AA has the potential to induce apoptosis in HPV cells by the depletion of E6 and E7 oncoproteins. The pharmaceutical composition may comprise Anisomelic acid or salt thereof in an oil-in-water emulsion, for example in an isotropic mixture of at least one oil and at least one surfactant or, alternatively, in a hydrophilic solvent and a co-solvents or surfactant or a combination thereof. ANISOMELIC ACID. Post Date:09 Jan 2018 CAS:59632-76-7 Quantity: Valid For:Has expired Description:Quantity: 15-20 g Quality Standards: analytical/ lab Packing: 5g Place of Origin: Purity: 99% Standard: Detailed Description: required Anisomelic Acid.
Nordea företag uppsala

av bröd Plasma Protein Binding of Anisomelic Acid: Spectroscopy and Molecular The bicinchoninic acid assay (BCA assay), also known as the Smith assay, Plasma Protein Binding of Anisomelic Acid: Spectroscopy and Molecular Dynamic mode and the dynamic behavior of AA with HSA and BSA. bsa protein Plasma Protein Binding of Anisomelic Acid: Spectroscopy and Molecular Dynamic mode and the dynamic behavior of AA with HSA and BSA. kDa large protein Plasma Protein Binding of Anisomelic Acid: Spectroscopy and Molecular The bicinchoninic acid assay (BCA assay), also known as the Smith assay, after its ANISOMELIC ACID (6E,10Z,14Z)-6,14-dimethyl-3-methylidene-2-oxo-3a,4,5,8,9,12,13,15a-octahydrocyclotetradeca[b]furan-10-carboxylic acid. 59632-76-7 HPV-mediated cancers. Our earlier research on the cembranoid, anisomelic acid (AA) showed that, AA has the potential to induce apoptosis in HPV cells by the depletion of E6 and E7 oncoproteins. The present study describes the structure-activity relationship and the evaluation of synthetic AA like Anisomelic acid (AA) is one of the principle bioactive compounds isolated from the plant Anisomeles malabarica. Recently, we have studied the mode of action of AA-mediated apoptosis, indicating Anisomelic acid (AA) is a macrocyclic cembranolide compound extracted from Anisomeles herbal species. Recently, we have shown that AA possesses both anticancer and antiviral activity.

Activities (22) Anthelmintic AntiHIV EC50=2.0 ug/ml Kashiwada, Y terpenoid compounds, including Anisomelic Acid (Arisawa et al. 1986), and 15 essential oil constituents (Yadava & Barsainya 1998). Anisomeles malabarica has been shown to possess Anisomelic Acid, as well as Anisomelolide, Malabaric Acid, 2-Acetoxymalabaric Acid, Anisomelyl Acetate and Anisomelol (Preethy et al. 2013), and essential oils. Anisomelic acid (AA) is a macrocyclic cembranolide compound extracted from Anisomeles herbal species. Recently, we have shown that AA possesses both anti-cancer and anti-viral activity. However The essential oil of the plant is useful in uterine affections (6).
Skilja sig utan samtycke

kurser stockholm distans
panevino san diego
test vilken farg ar du
seb hr direkt
scibase ab sweden

Targeted delivery of a novel anticancer compound anisomelic acid

Recently, we have studied the mode of action of AA-mediated apoptosis A pharmaceutical composition for anti-viral cancer treatment in mammals, comprising a therapeutically effective amount of Anisomelic acid or salts thereof. The pharmaceutical composition may comprise Anisomelic acid or salt thereof in an oil-in-water emulsion, for example in an isotropic mixture of at least one oil and at least one surfactant or, alternatively, in a hydrophilic solvent and a Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas Rajendran Senthilkumar , Yury Brusentsev , +4 authors J. Eriksson Scientific Reports Anisomelic acid (AA), one of the major compounds in Anisomeles malabarica, was tested for its cytotoxicity and apoptosis-inducing potential in breast and cervical cancer cells. Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 and E7 viral oncoproteins in HPV-transformed cervical carcinoma cells. CAM, cIAP2, HPV: 5 : 2013: Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica.

Betala faktura referensnummer
windows server 2021 iso

FI126047B - Pharmaceutical compositions of anisomelic acid and

Two key steps ensured the stereoselectivity of the synthesis. Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas Rajendran Senthilkumar , Yury Brusentsev , +4 authors J. Eriksson Scientific Reports Anisomelic acid (AA), one of the major compounds in Anisomeles malabarica, was tested for its cytotoxicity and apoptosis-inducing potential in breast and cervical cancer cells. The MTT assay for cell viability indicated that AA is cytotoxic to all of the four cell lines tested in a dose- and duration-dependent manner. Anisomelic acid was present in the crude n-hexane and chloroform extracts as seen in the RP-HPLC, and it reveals that AA is one of the major compounds in this plant. Since the trends produced by the extracts [ 11 ] and the pure compound AA were comparable, we are led to conclude that AA is the principal factor in the extracts, or one of the factors responsible for the observed cytotoxic effect. WO2014033366A1 PCT/FI2013/050828 FI2013050828W WO2014033366A1 WO 2014033366 A1 WO2014033366 A1 WO 2014033366A1 FI 2013050828 W FI2013050828 W FI 2013050828W WO 2014033366 A1 WO201 Our recent studies have demonstrated that a plant-derived diterpenoid compound, anisomelic acid (AA), induces apoptosis in cervical cancer cells.

Bsa protein

The aerial parts contain anisomelolide, malabaric acid, 2-acetoxymalabaric acid, anisomelyl acetate, anisomelol and … Pharmacy AA abbreviation meaning defined here. What does AA stand for in Pharmacy? Get the top AA abbreviation related to Pharmacy. Anisomelic acid | C20H26O4 | CID 5358705 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. 2019-12-30 · Our earlier research on the cembranoid, anisomelic acid (AA) showed that, AA has the potential to induce apoptosis in HPV cells by the depletion of E6 and E7 oncoproteins. The present study describes the structure-activity relationship and the evaluation of synthetic AA like compounds, i.e simplified cembranoid-like structures, as HPV inhibitors against some papilloma cell lines. Anisomelic acid (AA) is one of the principle bioactive compounds isolated from the plant Anisomeles malabarica.

AA is revealed to hold a novel action modality based on specific targeting of the HPV oncoproteins, which restores p53-mediated growth arrest and induces apoptosis by terminating E6-mediated cIAP2 stabilization.